Narrow escape problem (nonfiction)

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The narrow escape problem is a ubiquitous problem in biology, biophysics and cellular biology.

The formulation is the following: a Brownian particle (ion, molecule, or protein) is confined to a bounded domain (a compartment or a cell) by a reflecting boundary, except for a small window through which it can escape.

The narrow escape problem is that of calculating the mean escape time.

This time diverges as the window shrinks, thus rendering the calculation a singular perturbation problem.

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